Nitchakarn Noranate, Ph.D.
Instructor, Faculty of Medicine
King Mongkut’s Institute of Technology Ladkrabang
B.Sc. (Medical Technology), 1998
Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
Ph.D. (Tropical Medicine), 2007
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Thailand-Japan Research Collaboration Center on Emerging and Re-emerging infectious diseases, NIH Thailand
Ph.D Student Visiting Fellow
Pasteur Institute, Paris, France
My research interest is about infection and immunity. The main subject of my research is to study host-pathogen interaction to apply the knowledge for disease prevention, attenuation and control. Medical viruses and protozoan parasite particularly Plasmodium falciparum are pathogens of my interest.
My current research is on Chikungunya virus infection (CHIKV). CHIKV is transmitted by Aedes mosquitoes which habitat worldwide and unfortunately, there is no vaccine currently available. In my previous study, we produced chikungunya virus-like particles (CHIKVLP) and characterized its immunogenicity for vaccine candidate. The ongoing research is continuing development of vaccine and diagnostic kits for CHIKV detection and in addition for zika virus. Future research on viral infection of herpesvirus family are on the way.
Malaria is a mosquito borne disease caused by protozoan parasite Plasmodium spp. Plasmodium falciparum malaria infection is classified as either uncomplicated, severe, and cerebral malaria. Many factors can influence the clinical outcomes including host and parasite genetics. My current project is the study of P. falciparum genetic polymorphism and its correlation to different clinical outcomes.
From my previous research works, your research experience will be related to techniques in molecular biology in DNA and protein level, essential assays in virology and immunology as well as molecular microbial genetic epidemiology.
1. Noranate N, Takeda N, Chetanachan P, Sittisaman P, A AN, Anantapreecha S. Characterization of chikungunya virus-like particles. PLoS One. 2014;9(9):e108169.
2. Li YG, Siripanyaphinyo U, Tumkosit U, Noranate N, A An, Tao R, Kurosu T, Ikuta K, Takeda N, Anantapreecha S. Chikungunya virus induces a more moderate cytopathic effect in mosquito cells than in mammalian cells. Intervirology. 2013;56(1):6-12.
3. Li YG, Siripanyaphinyo U, Tumkosit U, Noranate N, A AN, Pan Y, Kameoka M, Kurosu T, Ikuta K, Takeda N, Anantapreecha S. Poly (I:C), an agonist of toll-like receptor-3, inhibits replication of the Chikungunya virus in BEAS-2B cells. Virol J. 2012;9:114.
4. Noranate N, Prugnolle F, Jouin H, Tall A, Marrama L, Sokhna C, Ekala MT, Guillotte M, Bischoff E, Bouchier C, Patarapotikul J, Ohashi J, Trape JF, Rogier C, Mercereau-Puijalon O. Population diversity and antibody selective pressure to Plasmodium falciparum MSP1 block2 locus in an African malaria-endemic setting. BMC Microbiol. 2009;9:219.
5. Noranate N, Durand R, Tall A, Marrama L, Spiegel A, Sokhna C, Pradines B, Cojean S, Guillotte M, Bischoff E, Ekala MT, Bouchier C, Fandeur T, Ariey F, Patarapotikul J, Le Bras J, Trape JF, Rogier C, Mercereau-Puijalon O. Rapid dissemination of Plasmodium falciparum drug resistance despite strictly controlled antimalarial use. PLoS One. 2007;2(1):e139.