Weerachat Sompong, M.T., Ph.D.
Instructor, Faculty of Medicine
King Mongkut’s Institute of Technology Ladkrabang
B.Sc. (Medical Technology), 2009
PhD. (Clinical Biochemistry and Molecular Medicine), 2014
Visiting Graduate Student
School of Veterinary Medicine, Louisiana State University, USA
The ultimate goal of my research is to discover the alternative agents from natural products for the treatment. I identify the bioactive compounds from plant extracts and study the underlying mechanism of many pharmacological activities by using in vitro model. I am interested in many activities including anti-oxidative, anti-hyperglycemic, anti-hyperlipidemic, anti-glycation, anti-apoptosis, anti-inflammatory, and anti-microbial activities.
Now I am studying the anti-hyperglycemic and anti-hyperlipidemic activities of Thai plant extracts. I identify the phytochemical compounds by using high performance liquid chromatography (HPLC). I also study the mechanisms of these extracts to inhibit the digestive enzymes of carbohydrate and lipid to delay the processes of digestion and absorption by using in vitro. In addition, I study the mechanism of glucose uptake in skeletal muscle cells. I also study the insulin secretion activity in pancreatic beta-cells. Moreover, I have another research to study the anti-apoptosis activity of cinnamic acid and its derivatives in pancreatic beta-cells. In this study, I use methylglyoxal as an inducer for cell apoptosis. Many methods are used for this research including cell viability assay (MTT assay), formation of reactive oxygen species, caspase-3 activity, and flow cytometry to detect apoptotic cells.
1. Meeprom A, Chan CB, Sompong W, Adisakwattana S. Isoferulic acid attenuates methylglyoxal-induced apoptosis in INS-1 rat pancreatic β-cell through mitochondrial survival pathways and increasing glyoxalase-1 activity. Biomed Pharmacother. 2018;101: 777-785.
2. Adisakwattana S, Thilavech T, Sompong W, Pasukamonset P. Interaction between ascorbic acid and gallic acid in a model of fructose-mediated protein glycation and oxidation. Electron J Biotechnol. 2017;27: 32-36.
3. Sompong W, Cheng H, Adisakwattana S. Ferulic acid prevents methylglyoxal-induced protein glycation, DNA damage, and apoptosis in pancreatic β-cells. J Physiol Biochem. 2017;73(1): 121-131.
4. Sompong W, Muangngam N, Kongpatpharnich A, Manacharoenlarp C, Amorworasin C, Suantawee T, Thilavech T, Adisakwattana S. The inhibitory activity of herbal medicines on the keys enzymes and steps related to carbohydrate and lipid digestion. BMC Complement Altern Med. 2016;16(1).
5. Nunthanawanich P, Sompong W, Sirikwanpong S, Mäkynen K, Adisakwattana S, Dahlan W, Ngamukote S. Moringa oleifera aqueous leaf extract inhibits reducing monosaccharide-induced protein glycation and oxidation of bovine serum albumin. Springerplus. 2016;5(1).
6. Sompong W, Adisakwattana S. Inhibitory effect of herbal medicines and their trapping abilities against methylglyoxal-derived advanced glycation end-products. BMC Complement Altern Med. 2015;15(394).
7. Meeprom A, Sompong W, Suantawee T, Thilavech T, Chan CB, Adisakwattana S. Isoferulic acid prevents methylglyoxal-induced protein glycation and DNA damage by free radical scavenging activity. BMC Complement Altern Med. 2015;15(346).
8. Sompong W, Cheng H, Adisakwattana S. Protective effects of ferulic acid on high glucose-induced protein glycation, lipid peroxidation, and membrane ion pump activity in human erythrocytes. PLoS One. 2015;10(6).
9. Sompong W, Meeprom A, Cheng H, Adisakwattana S. A comparative study of ferulic acid on different monosaccharide-mediated protein glycation and oxidative damage in bovine serum albumin. Molecules. 2013;18(11): 13886-13903.
10. Meeprom A, Sompong W, Chan CB, Adisakwattana S. Isoferulic acid, a new anti-glycation agent, inhibits fructose- and glucose-mediated protein glycation in vitro. Molecules. 2013;18(6): 6439-6454.